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          Published in ScienceDirect

          Development of an IgG-Fc fusion COVID-19 subunit vaccine, AKS-452

          AKS-452 is a biologically-engineered vaccine comprising an Fc fusion protein of the SARS-CoV-2 viral spike protein receptor binding domain antigen (Ag) and human IgG1 Fc (SP/RBD-Fc) in clinical development for the induction and augmentation of neutralizing IgG titers against SARS-CoV-2 viral infection to address the COVID-19 pandemic.

          Read the paper on ScienceDirect.com


          Published in the National Center for Biotechnology Information

          Disrupting Insulin and IGF Receptor Function in Cancer

          The insulin and insulin-like growth factor (IGF) system plays an important role in regulating normal cell proliferation and survival. However, the IGF system is also implicated in many malignancies, including breast cancer. Preclinical studies indicate several IGF blocking approaches, such as monoclonal antibodies and tyrosine kinase inhibitors, have promising therapeutic potential for treating diseases.

          Read the paper on the NCBI website


          Published in ResearchGate

          Abstract P1-21-05: A novel long-acting insulin for cancer therapy reduces xenograft tumor growth

          A link between obesity, metabolic dysfunction, and an increased risk in cancer mortality has been well established in several cancer types including, breast, colon, pancreatic, and prostate cancers. A likely mechanism driving this elevated risk is the associated increase in circulating insulin and insulin-like growth factor (IGF), which are known promoters of cancer growth and have been linked to shorter progression-free survival, and increased risk of metastatic disease and death in breast cancer patients. IGF receptor (IGF1R) targeting has been unsuccessful as insulin receptor (IR) also is functional in breast cancers.

          Read the paper on ResearchGate.com


          Published in the Journal of Veterinary Internal Medicine

          An ultra-long-acting recombinant insulin for the treatment of diabetes mellitus in cats

          Treatment of diabetes mellitus (DM) in cats typically requires insulin injections q12h-q24h, posing a major compliance barrier for caregivers. Novel treatments enabling decreased injection frequency while maintaining safety are highly desirable. Insulin fused with feline immunoglobulin fragment crystallizable (Fc) has an ultra-long plasma half-life because it recycles through cells where it is protected from proteolysis.

          Read the paper on the Online Library


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